Antinuclear Antibodies

Staining Pattern

Antigen Associations

Homogeneous

ds-DNA, ss-DNA, DNP, histones

Speckled

Sm, RNP, SS-B, Sci-70

Nucleolar

Multiple antigens (one is 4-6s nucleolus-specific RNA)

ACA (anticetromere)

Centromere

PCNA

Nuclear antigen found in proliferating cells